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Medimabs/HIV-1 (gp41) Human Monoclonal Antibody (50-69)/100 µg/MM-0260-P
Medimabs/HIV-1 (gp41) Human Monoclonal Antibody (50-69)/100 µg/MM-0260-P
商品编号：
MM-0260-P
品牌：
Medimabs inc
市场价：
¥10100.00
美元价：
8080.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
HIV-1 (gp41)
Target background:
Of the two types of Human immunodeficiency virus (HIV) which have been characterized, HIV-1 is more infective and is prevalent globally. The HIV virion is encapsulated by a viral envelope that contains complexes of surface proteins, which are important for the virus to attach and fuse to infect target cells. A precursor molecule known as gp160 (glycoprotein 160) is cleaved by proteases into gp120 (glycoprotein 120) and gp41 (glycoprotein 41), glycoproteins that make up the envelope proteins of HIV. Glycoprotein gp41 is embedded in the viral membrane and can interact with other gp41 proteins. The proteins gp41 and gp120 form a complex which is thought to undergo conformational changes in order to initiate membrane fusion of the virus with a cell.
Immunogen:
The antibody was generated from HIV-infected individuals by a method based on the Epstein-Barr virus transformation of peripheral blood mononuclear cells (PBMCs) followed by fusion with heteromyeloma cells.
Specificity: The antibody recognizes the HIV-1 protein gp41. (amino acids 579-613)
Clone ID:
50-69
Isotype:
IgG1 kappa
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
Reconstitute with deionized water. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Dadachova E - Pre-clinical evaluation of a 213Bi-labeled 2556 antibody to HIV-1 gp41 glycoprotein in HIV-1 mouse models as a reagent for HIV eradication.
2.-Li L - Different pattern of immunoglobulin gene usage by HIV-1 compared to non-HIV-1 antibodies derived from the same infected subject.
3.-Gorny MK - Preferential use of the VH5-51 gene segment by the human immune response to code for antibodies against the V3 domain of HIV-1.
4.-Nyambi PN - Conserved and exposed epitopes on intact, native, primary human immunodeficiency virus type 1 virions of group M.
5.-Gorny MK - Effects of oligomerization on the epitopes of the human immunodeficiency virus type 1 envelope glycoproteins.
6.-Gorny MK and Zolla-Pazner S - Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficien...
7.-Hioe CE - Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies.
8.-Laal S - Synergistic neutralization of human immunodeficiency virus type 1 by combinations of human monoclonal antibodies.
9.-Zolla-Pazner S - Serotyping of primary human immunodeficiency virus type 1 isolates from diverse geographic locations by flow cytometry.
10.-Xu JY - Epitope mapping of two immunodominant domains of gp41, the transmembrane protein of human immunodeficiency virus type 1, using ten human monoclonal...
11.-Robinson WE Jr - Two immunodominant domains of gp41 bind antibodies which enhance human immunodeficiency virus type 1 infection in vitro.
12.-Tyler DS - Identification of sites within gp41 that serve as targets for antibody-dependent cellular cytotoxicity by using human monoclonal antibodies.
13.-Gorny MK - Production of site-selected neutralizing human monoclonal antibodies against the third variable domain of the human immunodeficiency virus type 1 e...
14.-Gorny MK - Generation of human monoclonal antibodies to human immunodeficiency virus.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
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