Medimabs/SamD12 Rabbit Polyclonal Antibody/100 µL/MM-0227
商品编号：
MM-0227
品牌：
Medimabs inc
市场价：
¥5100.00
美元价：
4080.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
SamD12
Target background:
SamD10 and SamD12 are two recently discovered homolog proteins consisting of a SAM domain. These proteins are also known as Hyphen (HYP) or Aveugle (Ave) and they have been demonstrated to interact with the SAM domain of the Connector enhancer of KSR (CNK) downstream of RAS but a step upstream of RAF. A role for these proteins downstream of EGFR during eye and wing development of Drosophila has also been demonstrated. Heterodimerization of CNK/SAM has been shown to facilitate the recruitment of a KSR/MEK complex to CNK and bridge KSR/MEK to RAF which greatly enhances RAS-mediated RAF activation.
Target alias:
Sterile alpha motif (SAM) domain-containing protein 12, Hyphen D12, HYPD12, Aveugle
Specificity: The antibody recognizes the protein SamD12. The antibody does not cross-react with SamD10.
Clone ID:
---
Preservative:
None
Format:
Lyophilized serum
Recommend starting dilution:
If reconstituted with deionized water in 100 µl: WB 1:1000. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Clapéron A and Therrien M - KSR and CNK: two scaffolds regulating RAS-mediated RAF activation.
2.-Douziech M - A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila.
3.-Roignant JY - The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
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