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Medimabs/PTEN Mouse Monoclonal Antibody (6H2.1)/100 µg/MM-0204-P
Medimabs/PTEN Mouse Monoclonal Antibody (6H2.1)/100 µg/MM-0204-P
商品编号：
MM-0204-P
品牌：
Medimabs inc
市场价：
¥5700.00
美元价：
4560.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
PTEN
Target background:
Phosphatase and tensin homolog on chromosome ten (PTEN) is a ubiquitously expressed tumor suppressor which, in the cytoplasm, antagonizes the PI3K signaling pathway through its lipid phosphatase activity. Mutations of this gene are an important step in the development of many cancers since PTEN regulates essential cellular process such as growth and survival. PTEN is also found in the nucleus, and studies have demonstrated that its presence in the nucleus is regulated by SUMOylation and phosphorylation. Also, studies have showed that cells lacking nuclear PTEN are more sensitive to DNA damage.
Target alias:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase
Immunogen:
C-terminal peptide
Specificity: The antibody recognizes the C-terminal portion of PTEN.
Clone ID:
6H2.1
Isotype:
IgG2a kappa
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100 µl: WB 1:1000, IP 1:100, IHC 1:200. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Gimm O - Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors.
2.-Gimm O - Expression of the PTEN tumour suppressor protein during human development.
3.-Perren A - Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
