Medimabs/Rho鸟嘌呤交换因子山羊多克隆抗体/100µg/MM-0193-P
商品编号：
MM-0193-P
品牌：
Medimabs inc
市场价：
¥7100.00
美元价：
5680.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
Rho-Guanine Exchange Factor
Target background:
The human Rho guanine nucleotide exchange factor (RGNEF) is a homolog of mouse p190RhoGEF that has been recently identified as a novel human NFL mRNA binding protein in Amyotrophic Lateral Sclerosis (ALS) affected spinal cords. ALS - also known as Charcot's Disease, Lou Gehrig's disease and Motor Neuron Disease – is a rapidly progressive, and fatal, neuromuscular disease characterized by the gradual degeneration and death of motor neurons in the brain and spinal cord, which lead to progressive paralysis of the muscles.
Target alias:
RGNEF
Immunogen:
Peptide within the RNA binding domain of RNEGF
Specificity: The antibody recognizes a sequence on the RNA binding domain of human Rho-Guanine Nucleotide Exchange Factor (RGNEF) isoforms A and B. Competition test were done with a blocking peptide identical to the one used during immunization
Clone ID:
---
Preservative:
None
Format:
Lyophilized immunogen affinity purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100 µl: IP: 1ug/ml, IF: 1:100, IHC: 1:100-1:500. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Droppelmann CA - Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sclerosis.
2.-Keller BA - Co-aggregation of RNA binding proteins in ALS spinal motor neurons: evidence of a common pathogenic mechanism.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
