半胱氨酸天冬氨酸蛋白酶-6兔多克隆抗体/50µL/MM-0141切割的Medimabs/Tau
商品编号：
MM-0141
品牌：
Medimabs inc
市场价：
¥6700.00
美元价：
5360.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
Tau cleaved by caspase-6
Target background:
The tau protein is a microtubule-associated protein mainly expressed in neurons, which plays a crucial role in the neuronal cytoskeleton stabilization. The main role of tau proteins is to stabilize microtubules.Tau proteins are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in astrocytes and oligodendrocytes. Defects in tau proteins can result in dementias, such as Alzheimer's disease (AD). AD is a neurodegenerative pathology which is characterized by the presence of two types of neuropathological hallmarks: neurofibrillary tangles (NFTs) and senile plaques. NFTs are intraneuronal aggregations mainly composed of abnormally phosphorylated Tau. In neuropil threads (NPTs), NFTs, and neuritic plaques (NPs) of severe AD brains, highly abundant amounts of active caspase-6 and tau cleaved by caspase-6 (TauΔCsp6) have been found. Caspases are a family of cytosolic aspartate-specific cysteine proteases. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspase-6 has been associated with increasing β-amyloid peptide in primary cultures of human neurons. Caspase-6 has also been demonstrated to be active in NPTs, NFTs, and NPs in the hippocampus and temporal cortex in sporadic AD. Caspase-6 activation has been suggested to be an early event in AD and to precede the development of lesions.
Target alias:
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, MAPT, MAPTL, MTBT1, TAU
Specificity: The antibody recognizes the sequence (KSPVVSGD) in the human tau protein. It is expected that other species displaying the same amino acid in the tau protein will be recognized by the antibody
Clone ID:
---
Preservative:
None
Format:
Lyophilized serum
Recommend starting dilution:
If reconstituted with deionized water in 50 µl: WB 1:100-1:500; IP 1:100-1:500; IHC 1:2000-1:10000. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Albrecht S - Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
2.-Albrecht S - Activation of caspase-6 in aging and mild cognitive impairment.
3.-Guo H - Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer"s disease.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
