当前位置：
首页
>
产品中心 >
Polyclonal_antibody >
Medimabs/Itk (IL2-inducible T-cell kinase) Mouse Monoclonal Antibody (2F12)/100 µg/MM-0121-P
Medimabs/Itk (IL2-inducible T-cell kinase) Mouse Monoclonal Antibody (2F12)/100 µg/MM-0121-P
商品编号：
MM-0121-P
品牌：
Medimabs inc
市场价：
¥7100.00
美元价：
5680.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
Itk (IL2-inducible T-cell kinase)
Target background:
IL2-inducible T-cell kinase (Itk) is located in cell membrane of T-cell lines and natural killer cell lines and plays a role in T-cell proliferation and differentiation. Defects in Itk are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1).
Specificity: A highly specific and sensitive antibody against Itk. The antibody recognizes both native and denatured Itk (amino acids 1-26). No detectable cross reactivity with other Itk family members such as Btk or Tec. S
Clone ID:
2F12
Isotype:
IgG1
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100µL: WB 2 µg/ml. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Heyeck SD - Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.
2.-Wilcox HM and Berg LJ - Itk phosphorylation sites are required for functional activity in primary T cells.
3.-Miller AT - Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
