Medimabs/磷酸化朊蛋白（pPrP Ser43）兔多克隆抗体/50µL/MM-0112
商品编号：
MM-0112
品牌：
Medimabs inc
市场价：
¥6100.00
美元价：
4880.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
Phospho Prion Protein (pPrP Ser43)
Target background:
Prion related neurodegenerative diseases, called transmissible spongiform encephalopathies, are observed in many animal species. These diseases involve conversion of normal cellular prion protein (PrPc) into a form that is insoluble and resistant to proteases (PrPSc). The protease resistant form can polymerize into fibrils which accumulate in infected tissues and cause cell death and tissue damage. PrPs have an N-terminal signal sequence and a C-terminal linkage to glycosylphosphatidylinositol anchor. The mature protein is a glycosylated protein that associates with cell membranes. Phosphorylation of PrPC at Ser-43 by Cdk5 promotes proteinase K resistance, prion aggregation, and fibril formation in vitro. In addition, Ser-43 phosphorylation is upregulated in scrapie-infected mouse brain relative to controls. Thus, phosphorylation of Ser-43 may be an important mechanism leading conversion of PrPc to PrPSc and the onset of disease. The antibody was raised against Phospho Prion Protein (pPrP Ser43).
Target alias:
anti-Phospho Prion Protein, anti-Prion Protein, PrP, ASCR, PrP27-30, PrP33-35C , CD_antigen: CD230
Immunogen:
Phospho-peptide
Specificity: A highly specific and sensitive antibody against the phosphorylation of the Ser43 of the Prion Protein. The antibody reacts with the Ser43 (G[pSer]PGGNRYPC) of the Phosphorylated Prion Protein.
Clone ID:
---
Preservative:
None
Format:
Lyophilized serum
Recommend starting dilution:
If reconstituted with deionized water in 50 µL: ELISA (phospho peptide) 1:500,000; E (non-phospho peptide) 1:25,000 WB 1:100; IP 1:100; IHC 1:200-1:1000. Optimal dilution has to be determined by the user
Limitations:
Research Use Only
References:
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
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