Medimabs/错误折叠的SOD1小鼠单克隆抗体（A5C3）/200µL/MM-0070-3-P
商品编号：
MM-0070-3-P
品牌：
Medimabs inc
市场价：
¥9900.00
美元价：
7920.00
产品分类：
多克隆抗体
公司分类：
Polyclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
Misfolded SOD1
Target background:
Superoxide dismutase 1 (SOD1) is a soluble cytoplasmic and mitochondrial intermembrane space protein. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals in the body. Mutations in SOD1 cause familial amyotrophic lateral sclerosis type 1 (ALS1). These mutations have been linked to accumulation of harmful superoxide radicals, promotion of apoptosis, formation of aggregates of misfolded superoxide dismutase which are toxic and the continued stimulation of nerve cells that causes them to burn out and die.
Target alias:
Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, hSOD1, SOD1
Immunogen:
Recombinant human SOD1 G93A APO
Specificity: The antibody recognizes misfolded forms of mutant human SOD1 protein. IF: G93A, G85R, and G37R; WB (denatured): G93A, G127X and G37R; WB (native): G37R; IP: G93A, G127X and G37R.
Clone ID:
A5C3
Isotype:
IgG1
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 200 µL: IF 1:50 to 1:500; WB 1:250; IP 5 µL / 40 µL (Protein G beads / 300 µg of protein lysate). Optimal dilution must be determined by the user.
Limitations:
Research Use Only
References:
1.-Pickles S - ALS-linked misfolded SOD1 species have divergent impacts on mitochondria.
2.-Gros-Louis F - Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mo...
3.-Vande Velde C - Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.
4.-Audet JN - Methylene blue administration fails to confer neuroprotection in two amyotrophic lateral sclerosis mouse models.
5.-Lee JC - Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mi...
6.-Parone PA - Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in ...
7.-Roberts BR - Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of...
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
