Medimabs/RPTPsigma Mouse Monoclonal Antibody (17G7.2)/100 µg/MM-0020-P
商品编号：
MM-0020-P
品牌：
Medimabs inc
市场价：
¥9100.00
美元价：
7280.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
RPTPsigma
Target background:
Type IIa receptor protein tyrosine phosphatases (RPTPs) are a group of well-characterized proteins that are involved in axon growth and guidance during neural development.Members of this subfamily, RPTPσ, RPTPδ and LAR contain two cytoplasmic phosphatase domains and extracellular immunoglobulin domains followed by fibronectin type III repeats.RPTPσ is a type I transmembrane protein that has an apparent molecular weight of approximately 80 kDa.It is highly expressed by neurons in developing and adult mammalian nervous system.Knock-out mice for RPTPσ show growth retardation, delayed peripheral nerve development and high mortality rates.The role of RPTPσ in axon guidance during development suggests it could influence axon regeneration after injury in the adult mouse.It has been shown that RPTPσ slows axon regeneration in the adult injured CNS.
Target alias:
R-PTP-S, PTPNU-3, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma, Ptprs
Immunogen:
recombinant protein corresponding to the intracellular domain of mouse RPTP .
Specificity: The antibody recognizes the intracellular sub-unit of RPTPσ.
Clone ID:
17G7.2
Isotype:
IgG1 kappa
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100 µL: WB 1:2000. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Han KA - PTPσ Drives Excitatory Presynaptic Assembly via Various Extracellular and Intracellular Mechanisms.
2.-Li Y - Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion.
3.-Kurihara D and Yamashita T - Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein.
4.-Takahashi H - Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
5.-Thompson KM - Receptor protein tyrosine phosphatase sigma inhibits axonal regeneration and the rate of axon extension.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
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