Medimabs/TC-PTP（N术语）小鼠单克隆抗体（3E2）/100µg/MM-0018-P
商品编号：
MM-0018-P
品牌：
Medimabs inc
市场价：
¥7900.00
美元价：
6320.00
产品分类：
单克隆抗体
公司分类：
monoclonal_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Target:
TC-PTP (N term)
Target background:
The protein tyrosine phosphatases (PTP) belongs to a large family of enzymes involved in the regulation of cellular signaling and homeostasis, each possessing a 240 amino acid PTP domain.The T-cell protein tyrosine phosphatase (TC-PTP) is predominantly expressed in the hematopoietic lineage.TC-PTP null mice suffer severe defects in the hematopoietic compartment and die at 3-5 weeks of age from severe anemia.TC-PTP -/- murine embryonic fibroblasts have a slow progression through the G1 phase of the cell cycle and have compromised NF-kappaB activation.JAK 1 and 3 have been identified as physiological substrates of TC-PTP.Recent genetic studies have revealed an association between the PTPN2 (TC-PTP) gene and diseases like type 1 diabetes and Crohn’s disease.
Target alias:
T-cell protein tyrosine phosphatase, Protein-tyrosine phosphatase PTP-2, MPTP, Ptpn2, Ptpt
Immunogen:
N-terminal fragment of TC-PTP
Specificity: The antibody recognizes the N-terminal portion of TC-PTP; when used for Western blots the antibody detects one band in MEF cells extract, and 2 bands in spleen extract. The antibody recognizes 4 bands of TC-PTP from monkey
Clone ID:
3E2
Isotype:
IgG1
Preservative:
None
Format:
Lyophilized protein G purified in PBS pH7.4
Recommend starting dilution:
If reconstituted with deionized water in 100 µL: WB 1:1000. Optimal dilution has to be determined by the user.
Limitations:
Research Use Only
References:
1.-Isnard A - Impact of Leishmania infection on host macrophage nuclear physiology and nucleopore complex integrity.
2.-Merry TL - High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage.
3.-Bussières-Marmen S - Characterization of PTPN2 and its use as a biomarker.
4.-Kleppe M - Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia.
5.-Conrad M - 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.
6.-Simoncic PD - The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.
7.-Ibarra-Sánchez MJ - Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation.
Storage:
Lyophilized antibodies can be kept at 4ºC for up to 3 months and should be kept at -20ºC for long-term storage (2 years). To avoid freeze-thaw cycles, reconstituted antibodies should be aliquoted before freezing for long-term (1 year) storage (-80ºC) or kept at 4ºC for short-term usage (2 months). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made with the assay buffer. After the maximum long-term storage period (2 years lyophilized or 1 year reconstituted) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.
品牌介绍
Medimabs让我们的专家团队为您定制抗体的开发确定最佳方法：肽，蛋白质或DNA免疫。受益于他们的专业战略建议，可靠的抗原设计和快速合成抗体开发中最关键的一步是抗原策略和设计。为了使您的项目成功的机会最大化，我们将深入分析目标的结构，并找到最佳的选择以获得适合您的应用需求的抗体。整个项目可以根据您的最终应用进行定制（流式细胞仪，治疗，蛋白质印迹，免疫荧光，ELISA，免疫沉淀等）。我们可以获得广泛的免疫原，并且每种免疫原都有其优势。 合成肽蛋白质（细菌，酵母，昆虫或哺乳动物细胞表达模型） DNA免疫让我们指导您，为您的项目设计最佳抗原。
